Kenji Yamamoto Selected Research

Gingipain Cysteine Endopeptidases

4/2018	Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.
8/2014	A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy.
6/2008	Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system.
9/2007	A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells.
11/2006	Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
2/2005	A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.
12/2004	Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors.
11/2004	Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes.
12/2003	Suppression of virulence of Porphyromonas gingivalis by potent inhibitors specific for gingipains.
7/2003	[Gingipains as the determinants of periodontopathogenicity].

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Kenji Yamamoto Research Topics

Disease

13	Neoplasms (Cancer) 01/2015 - 11/2003
12	Infections 01/2020 - 05/2002
10	Parkinson Disease (Parkinson's Disease) 05/2021 - 02/2009
8	Periodontal Diseases (Periodontal Disease) 04/2018 - 07/2002
8	Autistic Disorder (Autism) 02/2009 - 09/2005
5	Schizophrenia (Dementia Praecox) 11/2021 - 02/2003
5	Inflammation (Inflammations) 01/2015 - 11/2004
5	Ovarian Neoplasms (Ovarian Cancer) 02/2011 - 05/2002
4	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 08/2011
3	Breast Neoplasms (Breast Cancer) 07/2014 - 01/2011
3	Human Influenza (Influenza) 01/2012 - 05/2003
3	Atopic Dermatitis (Atopic Eczema) 05/2009 - 07/2003
3	Chronic Periodontitis 09/2007 - 11/2004
3	Periodontal Pocket (Periodontal Pockets) 12/2004 - 06/2003
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/2023 - 07/2022
2	Tachycardia (Tachyarrhythmias) 04/2023 - 11/2017
2	Atrial Fibrillation 04/2023 - 11/2017
2	Neuromyelitis Optica (Devic's Disease) 04/2022 - 01/2020
2	Lewy Body Disease (Lewy Body Dementia) 06/2021 - 11/2019
2	Cognitive Dysfunction 02/2021 - 12/2018
2	Psychotic Disorders (Schizoaffective Disorder) 12/2018 - 10/2013
2	Ischemia 09/2015 - 01/2004
2	Carcinogenesis 03/2014 - 12/2008
2	Bacterial Infections (Bacterial Infection) 05/2009 - 07/2006
2	Systemic Vasculitis 08/2008 - 01/2007
2	Glomerulonephritis 08/2008 - 01/2007
2	Pathologic Processes 02/2008 - 11/2007
2	Neoplasm Metastasis (Metastasis) 11/2007 - 11/2003
2	Carcinoma (Carcinomatosis) 11/2007 - 03/2004
2	Neuroblastoma 02/2007 - 11/2005
2	Meningioma (Meningiomas) 09/2003 - 09/2002
1	Autism Spectrum Disorder 01/2024
1	Bradycardia 04/2023
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2023
1	Nocturnal Enuresis (Bedwetting) 07/2022
1	Iron Deficiencies 05/2022
1	Sleep Initiation and Maintenance Disorders (Insomnia) 05/2022
1	Ulcer 01/2022
1	Varicose Ulcer (Ulcer, Venous) 01/2022
1	Aortic Dissection 12/2021

Drug/Important Bio-Agent (IBA)

17	Cathepsin EIBA 01/2019 - 07/2003
12	Gingipain Cysteine EndopeptidasesIBA 04/2018 - 07/2002
8	Cysteine Proteases (Cysteine Protease)IBA 06/2008 - 06/2003
7	EnzymesIBA 01/2012 - 07/2002
5	Antipsychotic Agents (Antipsychotics)IBA 03/2021 - 02/2003
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 01/2004
4	CytokinesIBA 02/2014 - 07/2002
4	Paclitaxel (Taxol)FDA LinkGeneric 05/2005 - 05/2002
3	Rituximab (Mabthera)FDA Link 04/2022 - 01/2012
3	SynucleinsIBA 06/2021 - 03/2013
3	Levodopa (L Dopa)FDA LinkGeneric 05/2021 - 01/2014
3	Polysaccharides (Glycans)IBA 11/2016 - 11/2004
3	C-Reactive ProteinIBA 01/2015 - 01/2014
3	Peptide Hydrolases (Proteases)FDA Link 05/2014 - 07/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2014 - 11/2007
3	AntigensIBA 03/2011 - 11/2004
3	LigandsIBA 08/2010 - 08/2006
3	Glutamic Acid (Glutamate)FDA Link 09/2007 - 05/2003
3	Cisplatin (Platino)FDA LinkGeneric 10/2006 - 05/2002
2	landiololIBA 04/2023 - 11/2017
2	asenapine FDA Link 11/2021 - 01/2021
2	brexpiprazoleIBA 11/2021 - 01/2021
2	CalciumIBA 06/2021 - 01/2015
2	Donepezil (Aricept)FDA LinkGeneric 02/2021 - 12/2018
2	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 01/2021 - 01/2015
2	ApolipoproteinsIBA 12/2018 - 11/2006
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2017 - 02/2014
2	Biomarkers (Surrogate Marker)IBA 01/2015 - 01/2015
2	ChemokinesIBA 02/2014 - 09/2010
2	Amantadine (Aman)FDA LinkGeneric 01/2014 - 12/2010
2	Dopamine Agonists (Dopamine Agonist)IBA 01/2014 - 02/2009
2	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2010 - 02/2004
2	DNA (Deoxyribonucleic Acid)IBA 03/2010 - 01/2006
2	Hemagglutinins (Hemagglutinin)IBA 08/2008 - 08/2006
2	ChitosanIBA 08/2008 - 08/2006
2	Peroxidase (Myeloperoxidase)IBA 08/2008 - 01/2007
2	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 08/2008 - 01/2007
2	Lysine (L-Lysine)FDA Link 06/2008 - 07/2003
2	Aspartic Acid ProteasesIBA 02/2008 - 11/2007
2	OligosaccharidesIBA 08/2006 - 05/2003
2	Virulence Factors (Pathogenicity Factors)IBA 02/2005 - 11/2004
2	Anti-Allergic Agents (Antiallergic Agents)IBA 11/2004 - 11/2004
2	PlatinumIBA 03/2004 - 05/2002
1	Psychotropic Drugs (Psychoactive Drugs)IBA 12/2023
1	napabucasinIBA 03/2023
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 07/2022
1	Guanfacine (Tenex)FDA LinkGeneric 07/2022
1	Ferritins (Ferritin)IBA 05/2022
1	IronIBA 05/2022
1	Antihypertensive Agents (Antihypertensives)IBA 12/2021

Therapy/Procedure

9	Therapeutics 01/2022 - 11/2004
8	Drug Therapy (Chemotherapy) 07/2014 - 05/2002
3	Quantum Dots (Quantum Dot) 03/2011 - 01/2004
2	Transdermal Patch 04/2023 - 11/2017
2	Anesthesia 09/2021 - 04/2019
2	Adjuvant Chemotherapy 07/2014 - 10/2006
1	Duration of Therapy 01/2024
1	Electric Countershock (Cardioversion) 04/2023
1	Skin Care 01/2022
1	Radiofrequency Ablation 01/2022